Mimicking human riboflavin responsive neuromuscular disorders by silencing flad-1 gene in C. elegans: Alteration of vitamin transport and cholinergic transmission.

Leone, Piero; Tolomeo, Maria; Piancone, Elisabetta; Puzzovio, Pier Giorgio; De Giorgi, Carla; Indiveri, Cesare; Di Schiavi, Elia; Barile, Maria

Leone, Piero; Tolomeo, Maria; Piancone, Elisabetta; Puzzovio, Pier Giorgio; De Giorgi, Carla; Indiveri, Cesare; Di Schiavi, Elia; Barile, Maria.

Afiliação

Leone P; Department of Biosciences, Biotechnology, and Biopharmaceutics, University of Bari, Bari, Italy.
Tolomeo M; Department of Biosciences, Biotechnology, and Biopharmaceutics, University of Bari, Bari, Italy.
Piancone E; Department of Biosciences, Biotechnology, and Biopharmaceutics, University of Bari, Bari, Italy.
Puzzovio PG; Faculty of Medicine, Pharmacology and Experimental Therapeutics Unit, Institute for Drug Research, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel.
De Giorgi C; Department of Biosciences, Biotechnology, and Biopharmaceutics, University of Bari, Bari, Italy.
Indiveri C; Department DiBEST (Biologia, Ecologia, Scienze della Terra), Unit of Biochemistry and Molecular Biotechnology, University of Calabria, Arcavacata di Rende, Italy.
Di Schiavi E; Institute of Biosciences and Bioresources (IBBR) CNR, Naples, Italy.
Barile M; Department of Biosciences, Biotechnology, and Biopharmaceutics, University of Bari, Bari, Italy.

IUBMB Life ; 74(7): 672-683, 2022 07.

Article em En | MEDLINE | ID: mdl-34558787

Assuntos

Proteínas de Caenorhabditis elegans; Caenorhabditis elegans; Nucleotidiltransferases; Animais; Caenorhabditis elegans/genética; Caenorhabditis elegans/metabolismo; Proteínas de Caenorhabditis elegans/genética; Modelos Animais de Doenças; Flavina-Adenina Dinucleotídeo/metabolismo; Humanos; Doenças Neuromusculares/genética; Nucleotidiltransferases/genética; Riboflavina/metabolismo; Vitaminas/metabolismo

Palavras-chave

C. elegans; ETFDH; LSMFLAD; RNA interference; flad-1; rft-1; riboflavin therapy

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Caenorhabditis elegans / Proteínas de Caenorhabditis elegans / Nucleotidiltransferases Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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