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Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta.
Rofo, Fadi; Buijs, Jos; Falk, Ronny; Honek, Ken; Lannfelt, Lars; Lilja, Anna M; Metzendorf, Nicole G; Gustavsson, Tobias; Sehlin, Dag; Söderberg, Linda; Hultqvist, Greta.
Afiliação
  • Rofo F; Protein Drug Design, Faculty of Pharmacy, Uppsala University, 75124, Uppsala, Sweden.
  • Buijs J; Department of Immunology, Genetics and Pathology, Uppsala University, 75185, Uppsala, Sweden.
  • Falk R; Ridgeview Instruments, 75237, Uppsala, Sweden.
  • Honek K; BioArctic AB, 11251, Stockholm, Sweden.
  • Lannfelt L; BioArctic AB, 11251, Stockholm, Sweden.
  • Lilja AM; BioArctic AB, 11251, Stockholm, Sweden.
  • Metzendorf NG; Department of Public Health and Caring Sciences, Uppsala University, 75185, Uppsala, Sweden.
  • Gustavsson T; BioArctic AB, 11251, Stockholm, Sweden.
  • Sehlin D; Protein Drug Design, Faculty of Pharmacy, Uppsala University, 75124, Uppsala, Sweden.
  • Söderberg L; Department of Public Health and Caring Sciences, Uppsala University, 75185, Uppsala, Sweden.
  • Hultqvist G; Department of Public Health and Caring Sciences, Uppsala University, 75185, Uppsala, Sweden.
Transl Neurodegener ; 10(1): 38, 2021 09 28.
Article em En | MEDLINE | ID: mdl-34579778
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos beta-Amiloides / Doença de Alzheimer Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos beta-Amiloides / Doença de Alzheimer Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article