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Increased glucosylceramide production leads to decreased cell energy metabolism and lowered tumor marker expression in non-cancerous liver cells.
Wegner, Marthe-Susanna; Schömel, Nina; Olzomer, Ellen M; Trautmann, Sandra; Olesch, Catherine; Byrne, Frances L; Brüne, Bernhard; Gurke, Robert; Ferreirós, Nerea; Weigert, Andreas; Geisslinger, Gerd; Hoehn, Kyle L.
Afiliação
  • Wegner MS; Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, House 74, Theodor Stern-Kai 7, 60590, Frankfurt am Main, Germany. wegner@med.uni-frankfurt.de.
  • Schömel N; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, 2052, Australia. wegner@med.uni-frankfurt.de.
  • Olzomer EM; Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, House 74, Theodor Stern-Kai 7, 60590, Frankfurt am Main, Germany.
  • Trautmann S; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, 2052, Australia.
  • Olesch C; Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, House 74, Theodor Stern-Kai 7, 60590, Frankfurt am Main, Germany.
  • Byrne FL; Faculty of Medicine, Institute of Biochemistry I, Johann Wolfgang Goethe University, Theodor Stern-Kai 7, 60590, Frankfurt am Main, Germany.
  • Brüne B; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, 2052, Australia.
  • Gurke R; Faculty of Medicine, Institute of Biochemistry I, Johann Wolfgang Goethe University, Theodor Stern-Kai 7, 60590, Frankfurt am Main, Germany.
  • Ferreirós N; Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, House 74, Theodor Stern-Kai 7, 60590, Frankfurt am Main, Germany.
  • Weigert A; Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Theodor Stern-Kai 7, 60590, Frankfurt am Main, Germany.
  • Geisslinger G; Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, House 74, Theodor Stern-Kai 7, 60590, Frankfurt am Main, Germany.
  • Hoehn KL; Faculty of Medicine, Institute of Biochemistry I, Johann Wolfgang Goethe University, Theodor Stern-Kai 7, 60590, Frankfurt am Main, Germany.
Cell Mol Life Sci ; 78(21-22): 7025-7041, 2021 Nov.
Article em En | MEDLINE | ID: mdl-34626204
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Metabolismo Energético / Glucosilceramidas / Fígado Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Metabolismo Energético / Glucosilceramidas / Fígado Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article