To export, or not to export: how nuclear export factor variants resolve Piwi's dilemma.
Biochem Soc Trans
; 49(5): 2073-2079, 2021 11 01.
Article
em En
| MEDLINE
| ID: mdl-34643228
ABSTRACT
Piwi-interacting RNAs (piRNAs) defend animal gonads by guiding PIWI-clade Argonaute proteins to silence transposons. The nuclear Piwi/piRNA complexes confer transcriptional repression of transposons, which is accompanied with heterochromatin formation at target loci. On the other hand, piRNA clusters, genomic loci that transcribe piRNA precursors composed of transposon fragments, are often recognized by piRNAs to define their heterochromatic identity. Therefore, Piwi/piRNA complexes must resolve this conundrum of silencing transposons while allowing the expression of piRNA precursors, at least in Drosophila germlines. This review is focused on recent advances how the piRNA pathway deals with this genetic conflict.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
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Núcleo Celular
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Inativação Gênica
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Proteínas de Drosophila
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RNA Interferente Pequeno
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Drosophila melanogaster
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Proteínas Argonautas
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article