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A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation.
Sonobe, Yoshifumi; Aburas, Jihad; Krishnan, Gopinath; Fleming, Andrew C; Ghadge, Ghanashyam; Islam, Priota; Warren, Eleanor C; Gu, Yuanzheng; Kankel, Mark W; Brown, André E X; Kiskinis, Evangelos; Gendron, Tania F; Gao, Fen-Biao; Roos, Raymond P; Kratsios, Paschalis.
Afiliação
  • Sonobe Y; University of Chicago Medical Center, 5841S. Maryland Avenue, Chicago, IL, 60637, USA.
  • Aburas J; Department of Neurology, University of Chicago Medical Center, 5841S. Maryland Avenue, Chicago, IL, 60637, USA.
  • Krishnan G; The Grossman Institute for Neuroscience, Quantitative Biology, and Human Behavior, University of Chicago, Chicago, IL, USA.
  • Fleming AC; University of Chicago Medical Center, 5841S. Maryland Avenue, Chicago, IL, 60637, USA.
  • Ghadge G; The Grossman Institute for Neuroscience, Quantitative Biology, and Human Behavior, University of Chicago, Chicago, IL, USA.
  • Islam P; Department of Neurobiology, University of Chicago, Chicago, IL, USA.
  • Warren EC; Department of Neurology, University of Massachusetts Medical School, Worcester, MA, 01605, USA.
  • Gu Y; The Ken & Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, USA.
  • Kankel MW; University of Chicago Medical Center, 5841S. Maryland Avenue, Chicago, IL, 60637, USA.
  • Brown AEX; Department of Neurology, University of Chicago Medical Center, 5841S. Maryland Avenue, Chicago, IL, 60637, USA.
  • Kiskinis E; The Grossman Institute for Neuroscience, Quantitative Biology, and Human Behavior, University of Chicago, Chicago, IL, USA.
  • Gendron TF; MRC London Institute of Medical Sciences, London, UK.
  • Gao FB; Institute of Clinical Sciences, Imperial College London, London, UK.
  • Roos RP; MRC London Institute of Medical Sciences, London, UK.
  • Kratsios P; Institute of Clinical Sciences, Imperial College London, London, UK.
Nat Commun ; 12(1): 6025, 2021 10 15.
Article em En | MEDLINE | ID: mdl-34654821
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Caenorhabditis elegans / Demência Frontotemporal / Proteína C9orf72 / Esclerose Lateral Amiotrófica Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Caenorhabditis elegans / Demência Frontotemporal / Proteína C9orf72 / Esclerose Lateral Amiotrófica Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article