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Sensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF.
Monkley, Susan; Overed-Sayer, Catherine; Parfrey, Helen; Rassl, Doris; Crowther, Damian; Escudero-Ibarz, Leire; Davis, Nicola; Carruthers, Alan; Berks, Richard; Coetzee, Marisa; Kolosionek, Ewa; Karlsson, Maria; Griffin, Leia R; Clausen, Maryam; Belfield, Graham; Hogaboam, Cory M; Murray, Lynne A.
Afiliação
  • Monkley S; Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Overed-Sayer C; Bioscience COPD/IPF, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
  • Parfrey H; Cambridge Interstitial Lung Disease Service, Royal Papworth Hospital, Cambridge, UK.
  • Rassl D; Royal Papworth Hospital, Cambridge, UK.
  • Crowther D; Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
  • Escudero-Ibarz L; Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
  • Davis N; Bioscience COPD/IPF, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
  • Carruthers A; Bioscience COPD/IPF, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
  • Berks R; Biological Services Group, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, UK.
  • Coetzee M; Babraham Institute, Cambridge, UK.
  • Kolosionek E; Bioscience COPD/IPF, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Karlsson M; Bioscience COPD/IPF, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Griffin LR; Bioscience COPD/IPF, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
  • Clausen M; Translational Genomics, Discovery Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Belfield G; Translational Genomics, Discovery Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Hogaboam CM; Cedars-Sinai Department of Medicine, Los Angeles, CA, 90048, USA.
  • Murray LA; Bioscience COPD/IPF, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK. lynnemurray@hotmail.com.
Sci Rep ; 11(1): 21584, 2021 11 03.
Article em En | MEDLINE | ID: mdl-34732748
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrose / Senescência Celular / Proteína Fosfatase 1 / Resposta a Proteínas não Dobradas Tipo de estudo: Prognostic_studies Limite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrose / Senescência Celular / Proteína Fosfatase 1 / Resposta a Proteínas não Dobradas Tipo de estudo: Prognostic_studies Limite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article