Gambogic amide inhibits angiogenesis by suppressing VEGF/VEGFR2 in endothelial cells in a TrkA-independent manner.

Sui, Tongtong; Qiu, Bojun; Qu, Jiaorong; Wang, Yuxin; Ran, Kunnian; Han, Wei; Peng, Xiaozhong

Sui, Tongtong; Qiu, Bojun; Qu, Jiaorong; Wang, Yuxin; Ran, Kunnian; Han, Wei; Peng, Xiaozhong.

Afiliação

Sui T; State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.
Qiu B; State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.
Qu J; State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.
Wang Y; State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.
Ran K; State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.
Han W; State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.
Peng X; State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.

Pharm Biol ; 59(1): 1566-1575, 2021 Dec.

Article em En | MEDLINE | ID: mdl-34767490

Assuntos

Inibidores da Angiogênese/farmacologia; Células Endoteliais/efeitos dos fármacos; Xantonas/farmacologia; Inibidores da Angiogênese/administração & dosagem; Animais; Apoptose/efeitos dos fármacos; Linhagem Celular; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Galinhas; Membrana Corioalantoide/irrigação sanguínea; Membrana Corioalantoide/efeitos dos fármacos; Relação Dose-Resposta a Droga; Células Endoteliais/metabolismo; Células Endoteliais da Veia Umbilical Humana/efeitos dos fármacos; Humanos; Receptor trkA/metabolismo; Fator A de Crescimento do Endotélio Vascular/metabolismo; Receptor 2 de Fatores de Crescimento do Endotélio Vascular/metabolismo; Xantonas/administração & dosagem

Palavras-chave

AKT/mTOR; Antiangiogenic; PLCÎ³/Erk1/2; anticancer; phytochemicals

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores da Angiogênese / Células Endoteliais / Xantonas Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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