Structural model of human PORCN illuminates disease-associated variants and drug-binding sites.

Yu, Jia; Liao, Pei-Ju; Xu, Weijun; Jones, Julie R; Everman, David B; Flanagan-Steet, Heather; Keller, Thomas H; Virshup, David M

Yu, Jia; Liao, Pei-Ju; Xu, Weijun; Jones, Julie R; Everman, David B; Flanagan-Steet, Heather; Keller, Thomas H; Virshup, David M.

Afiliação

Yu J; Programme in Cancer and Stem Cell Biology, Duke-NUS Medical School, 169857, Singapore.
Liao PJ; Programme in Cancer and Stem Cell Biology, Duke-NUS Medical School, 169857, Singapore.
Xu W; Discovery Chemistry, Experimental Drug Development Centre, 10 Biopolis Road, Chromos, 138670, Singapore.
Jones JR; JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA.
Everman DB; JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA.
Flanagan-Steet H; JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA.
Keller TH; Discovery Chemistry, Experimental Drug Development Centre, 10 Biopolis Road, Chromos, 138670, Singapore.
Virshup DM; Programme in Cancer and Stem Cell Biology, Duke-NUS Medical School, 169857, Singapore.

J Cell Sci ; 134(24)2021 12 15.

Article em En | MEDLINE | ID: mdl-34817055

Assuntos

Hipoplasia Dérmica Focal; Preparações Farmacêuticas; Aciltransferases/genética; Animais; Domínio Catalítico; Humanos; Proteínas de Membrana/genética; Modelos Estruturais

Palavras-chave

Focal dermal hypoplasia; MBOAT; PORCN; Split-hand/foot malformation; Wnt inhibitors; Wnt signaling

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hipoplasia Dérmica Focal / Preparações Farmacêuticas Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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