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Chiral Quantum Metamaterial for Hypersensitive Biomolecule Detection.
Hajji, Maryam; Cariello, Michele; Gilroy, Cameron; Kartau, Martin; Syme, Christopher D; Karimullah, Affar; Gadegaard, Nikolaj; Malfait, Aurélie; Woisel, Patrice; Cooke, Graeme; Peveler, William J; Kadodwala, Malcolm.
Afiliação
  • Hajji M; School of Chemistry, University of Glasgow, Glasgow G12 8QQ, United Kingdom.
  • Cariello M; School of Chemistry, University of Glasgow, Glasgow G12 8QQ, United Kingdom.
  • Gilroy C; School of Chemistry, University of Glasgow, Glasgow G12 8QQ, United Kingdom.
  • Kartau M; School of Chemistry, University of Glasgow, Glasgow G12 8QQ, United Kingdom.
  • Syme CD; School of Chemistry, University of Glasgow, Glasgow G12 8QQ, United Kingdom.
  • Karimullah A; School of Chemistry, University of Glasgow, Glasgow G12 8QQ, United Kingdom.
  • Gadegaard N; School of Engineering, Rankine Building, University of Glasgow, Glasgow G12 8LT, United Kingdom.
  • Malfait A; Univ. Lille, CNRS, INRAE, Centrale Lille, UMR 8207 - UMET - Unité Matériaux et Transformations, F-59000 Lille, France.
  • Woisel P; Univ. Lille, CNRS, INRAE, Centrale Lille, UMR 8207 - UMET - Unité Matériaux et Transformations, F-59000 Lille, France.
  • Cooke G; School of Chemistry, University of Glasgow, Glasgow G12 8QQ, United Kingdom.
  • Peveler WJ; School of Chemistry, University of Glasgow, Glasgow G12 8QQ, United Kingdom.
  • Kadodwala M; School of Chemistry, University of Glasgow, Glasgow G12 8QQ, United Kingdom.
ACS Nano ; 15(12): 19905-19916, 2021 12 28.
Article em En | MEDLINE | ID: mdl-34846858
ABSTRACT
Chiral biological and pharmaceutical molecules are analyzed with phenomena that monitor their very weak differential interaction with circularly polarized light. This inherent weakness results in detection levels for chiral molecules that are inferior, by at least six orders of magnitude, to the single molecule level achieved by state-of-the-art chirally insensitive spectroscopic measurements. Here, we show a phenomenon based on chiral quantum metamaterials (CQMs) that overcomes these intrinsic limits. Specifically, the emission from a quantum emitter, a semiconductor quantum dot (QD), selectively placed in a chiral nanocavity is strongly perturbed when individual biomolecules (here, antibodies) are introduced into the cavity. The effect is extremely sensitive, with six molecules per nanocavity being easily detected. The phenomenon is attributed to the CQM being responsive to significant local changes in the optical density of states caused by the introduction of the biomolecule into the cavity. These local changes in the metamaterial electromagnetic environment, and hence the biomolecules, are invisible to "classical" light-scattering-based measurements. Given the extremely large effects reported, our work presages next generation technologies for rapid hypersensitive measurements with applications in nanometrology and biodetection.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Pontos Quânticos Tipo de estudo: Diagnostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Pontos Quânticos Tipo de estudo: Diagnostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article