Tau phosphorylation sites serine202 and serine396 are differently altered in chronic traumatic encephalopathy and Alzheimer's disease.
Alzheimers Dement
; 18(8): 1511-1522, 2022 08.
Article
em En
| MEDLINE
| ID: mdl-34854540
ABSTRACT
INTRODUCTION:
Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repetitive head impacts (RHI) typically sustained by contact sport athletes. Post-translation modifications to tau in CTE have not been well delineated or compared to Alzheimer's disease (AD).METHODS:
We measured phosphorylated tau epitopes within dorsolateral frontal cortex from post mortem brains with neither CTE nor AD (n = 108), CTE (n = 109), AD (n = 223), and both CTE and AD (n = 33).RESULTS:
Levels of hyperphosphorylated tau (p-tau)202 , p-tau231 , and p-tau396 were significantly increased in CTE. Total years of RHI exposure was significantly associated with increased p-tau202 levels (P = .001), but not p-tau396 . Instead, p-tau396 was most closely related to amyloid beta (Aß)1-42 levels (P < .001). The p-tau202p-tau396 ratio was significantly increased in early and late CTE compared to AD.DISCUSSION:
In frontal cortex, p-tau202 is the most upregulated p-tau species in CTE, while p-tau396 is most increased in AD. p-tau202 and p-tau396 measurements may aid in developing biomarkers for disease.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Doença de Alzheimer
/
Encefalopatia Traumática Crônica
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article