Double-Modified Bacterial Cellulose/Soy Protein Isolate Composites by Laser Hole Forming and Selective Oxidation Used for Urethral Repair.
Biomacromolecules
; 23(1): 291-302, 2022 01 10.
Article
em En
| MEDLINE
| ID: mdl-34874163
ABSTRACT
In this study, a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI), a new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth, was prepared. Bacterial cellulose (BC) was physically and chemically modified by laser hole forming and selective oxidation to obtain the double-modified bacterial cellulose (DMBC). The soybean protein isolate (SPI) was compounded on DMBC to obtain DMBC/SPI with better biocompatibility. DMBC/SPI was used to repair the damaged urethra in rabbits. The results showed that DMBC/SPI was beneficial to heal the damaged urethra and did not cause a milder inflammatory response. The repaired urethra was smooth and continuous. DMBC/SPI has a good urethral repair effect and is expected to be used as a new urethral reconstruction material in clinical applications. In addition, FT-IR spectroscopy, SEM, static contact angle measurements, mechanical property investigation, and cell experiments were also performed to characterize the properties of DMBC/SPI composites.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Uretra
/
Proteínas de Soja
/
Engenharia Tecidual
Limite:
Animals
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article