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Acetoacetate protects macrophages from lactic acidosis-induced mitochondrial dysfunction by metabolic reprograming.
Adam, Clément; Paolini, Léa; Gueguen, Naïg; Mabilleau, Guillaume; Preisser, Laurence; Blanchard, Simon; Pignon, Pascale; Manero, Florence; Le Mao, Morgane; Morel, Alain; Reynier, Pascal; Beauvillain, Céline; Delneste, Yves; Procaccio, Vincent; Jeannin, Pascale.
Afiliação
  • Adam C; Univ Angers, Université de Nantes, INSERM, CRCINA, LabEx IGO, SFR ICAT, F-49000, Angers, France.
  • Paolini L; Univ Angers, Université de Nantes, INSERM, CRCINA, LabEx IGO, SFR ICAT, F-49000, Angers, France.
  • Gueguen N; Univ Angers, CHU d'Angers, INSERM, CNRS, MitoVasc, SFR ICAT, F-49000, Angers, France.
  • Mabilleau G; Département de Biochimie et Génétique, CHU d'Angers, Angers, France.
  • Preisser L; GEROM, Université d'Angers, Angers, France.
  • Blanchard S; Département de Pathologie Cellulaire et Tissulaire, CHU d'Angers, Angers, France.
  • Pignon P; Univ Angers, Université de Nantes, INSERM, CRCINA, LabEx IGO, SFR ICAT, F-49000, Angers, France.
  • Manero F; Univ Angers, Université de Nantes, INSERM, CRCINA, LabEx IGO, SFR ICAT, F-49000, Angers, France.
  • Le Mao M; Laboratoire d'Immunologie et Allergologie, CHU d'Angers, Angers, France.
  • Morel A; Univ Angers, Université de Nantes, INSERM, CRCINA, LabEx IGO, SFR ICAT, F-49000, Angers, France.
  • Reynier P; Univ Angers, SFR ICAT, SCIAM, F-49000, Angers, France.
  • Beauvillain C; Univ Angers, CHU d'Angers, INSERM, CNRS, MitoVasc, SFR ICAT, F-49000, Angers, France.
  • Delneste Y; Univ Angers, Université de Nantes, INSERM, CRCINA, LabEx IGO, SFR ICAT, F-49000, Angers, France.
  • Procaccio V; Institut de Cancérologie de l'Ouest, F-49000, Angers, France.
  • Jeannin P; Laboratoire de Biochimie et biologie moléculaire, CHU d'Angers, Angers, France.
Nat Commun ; 12(1): 7115, 2021 12 08.
Article em En | MEDLINE | ID: mdl-34880237
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Acidose Láctica / Substâncias Protetoras / Macrófagos / Mitocôndrias / Acetoacetatos Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Acidose Láctica / Substâncias Protetoras / Macrófagos / Mitocôndrias / Acetoacetatos Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article