Ribavirin inhibits the growth and ascites formation of hepatocellular carcinoma through downregulation of type I CARM1 and type II PRMT5.

Tian, Yizhen; Yang, Weihu; Yang, Ruiying; Zhang, Qingqing; Hao, Luyang; Bian, Enze; Yang, Yuquan; Huang, Xuewei; Wu, Yongjie; Zhang, Baolai

Tian, Yizhen; Yang, Weihu; Yang, Ruiying; Zhang, Qingqing; Hao, Luyang; Bian, Enze; Yang, Yuquan; Huang, Xuewei; Wu, Yongjie; Zhang, Baolai.

Afiliação

Tian Y; Department of Pharmacology, School of Basic Medical Sciences, Lanzhou University; Lanzhou 730000, People's Republic of China.
Yang W; Gansu Provincial Maternity and Child-Care Hospital, Lanzhou 730050, People's Republic of China.
Yang R; Department of Pharmacology, School of Basic Medical Sciences, Lanzhou University; Lanzhou 730000, People's Republic of China.
Zhang Q; Department of Pharmacology, School of Basic Medical Sciences, Lanzhou University; Lanzhou 730000, People's Republic of China.
Hao L; Department of Pharmacology, School of Basic Medical Sciences, Lanzhou University; Lanzhou 730000, People's Republic of China.
Bian E; Department of Pharmacology, School of Basic Medical Sciences, Lanzhou University; Lanzhou 730000, People's Republic of China.
Yang Y; Department of Pharmacology, School of Basic Medical Sciences, Lanzhou University; Lanzhou 730000, People's Republic of China.
Huang X; Department of Pharmacology, School of Basic Medical Sciences, Lanzhou University; Lanzhou 730000, People's Republic of China.
Wu Y; Department of Pharmacology, School of Basic Medical Sciences, Lanzhou University; Lanzhou 730000, People's Republic of China.
Zhang B; Department of Pharmacology, School of Basic Medical Sciences, Lanzhou University; Lanzhou 730000, People's Republic of China. Electronic address: zhangbl@lzu.edu.cn.

Toxicol Appl Pharmacol ; 435: 115829, 2022 01 15.

Article em En | MEDLINE | ID: mdl-34919946

Assuntos

Antimetabólitos Antineoplásicos/farmacologia; Ascite/tratamento farmacológico; Carcinoma Hepatocelular/tratamento farmacológico; Neoplasias Hepáticas/tratamento farmacológico; Proteína-Arginina N-Metiltransferases/antagonistas & inibidores; Ribavirina/farmacologia; Animais; Carcinoma Hepatocelular/genética; Carcinoma Hepatocelular/patologia; Linhagem Celular Tumoral; Relação Dose-Resposta a Droga; Regulação para Baixo/efeitos dos fármacos; Epigênese Genética/efeitos dos fármacos; Fator de Iniciação 4E em Eucariotos/biossíntese; Fator de Iniciação 4E em Eucariotos/genética; Humanos; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/patologia; Camundongos; Proteína-Arginina N-Metiltransferases/genética; Fator A de Crescimento do Endotélio Vascular/antagonistas & inibidores; Fator A de Crescimento do Endotélio Vascular/genética; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

CARM1; HCC; PRMT5; Ribavirin; VEGF; eIF4E

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína-Arginina N-Metiltransferases / Ascite / Ribavirina / Carcinoma Hepatocelular / Neoplasias Hepáticas / Antimetabólitos Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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