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Predicting Outcome in Guillain-Barré Syndrome: International Validation of the Modified Erasmus GBS Outcome Score.
Doets, Alex Y; Lingsma, Hester F; Walgaard, Christa; Islam, Badrul; Papri, Nowshin; Davidson, Amy; Yamagishi, Yuko; Kusunoki, Susumu; Dimachkie, Mazen M; Waheed, Waqar; Kolb, Noah; Islam, Zhahirul; Mohammad, Quazi Deen; Harbo, Thomas; Sindrup, Soren H; Chavada, Govindsinh; Willison, Hugh J; Casasnovas, Carlos; Bateman, Kathleen; Miller, James A L; van den Berg, Bianca; Verboon, Christine; Roodbol, Joyce; Leonhard, Sonja E; Benedetti, Luana; Kuwabara, Satoshi; Van den Bergh, Peter; Monges, Soledad; Marfia, Girolama A; Shahrizaila, Nortina; Galassi, Giuliana; Péréon, Yann; Bürmann, Jan; Kuitwaard, Krista; Kleyweg, Ruud P; Marchesoni, Cintia; Sedano Tous, María J; Querol, Luis; Illa, Isabel; Wang, Yuzhong; Nobile-Orazio, Eduardo; Rinaldi, Simon; Schenone, Angelo; Pardo, Julio; Vermeij, Frederique H; Lehmann, Helmar C; Granit, Volkan; Cavaletti, Guido; Gutiérrez-Gutiérrez, Gerardo; Barroso, Fabio A.
Afiliação
  • Doets AY; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Lingsma HF; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Walgaard C; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Islam B; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Papri N; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Davidson A; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Yamagishi Y; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Kusunoki S; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Dimachkie MM; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Waheed W; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Kolb N; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Islam Z; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Mohammad QD; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Harbo T; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Sindrup SH; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Chavada G; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Willison HJ; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Casasnovas C; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Bateman K; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Miller JAL; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • van den Berg B; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Verboon C; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Roodbol J; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Leonhard SE; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Benedetti L; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Kuwabara S; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Van den Bergh P; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Monges S; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Marfia GA; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Shahrizaila N; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Galassi G; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Péréon Y; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Bürmann J; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Kuitwaard K; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Kleyweg RP; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Marchesoni C; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Sedano Tous MJ; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Querol L; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Illa I; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Wang Y; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Nobile-Orazio E; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Rinaldi S; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Schenone A; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Pardo J; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Vermeij FH; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Lehmann HC; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Granit V; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Cavaletti G; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Gutiérrez-Gutiérrez G; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
  • Barroso FA; From the Departments of Neurology (A.Y.D., C.W., B.v.d.B., C.V., J.R., S.E.L., K.K., B.C.J.), Public Health (H.F.L.), and Immunology (B.C.J.), Erasmus MC, University Medical Centre Rotterdam; Department of Neurology (C.W., J.P.A.S.), Maasstad Hospital, Rotterdam, the Netherlands; Laboratory of Gut-B
Neurology ; 98(5): e518-e532, 2022 02 01.
Article em En | MEDLINE | ID: mdl-34937789
BACKGROUND AND OBJECTIVES: The clinical course and outcome of the Guillain-Barré syndrome (GBS) are diverse and vary among regions. The modified Erasmus GBS Outcome Score (mEGOS), developed with data from Dutch patients, is a clinical model that predicts the risk of walking inability in patients with GBS. The study objective was to validate the mEGOS in the International GBS Outcome Study (IGOS) cohort and to improve its performance and region specificity. METHODS: We used prospective data from the first 1,500 patients included in IGOS, aged ≥6 years and unable to walk independently. We evaluated whether the mEGOS at entry and week 1 could predict the inability to walk unaided at 4 and 26 weeks in the full cohort and in regional subgroups, using 2 measures for model performance: (1) discrimination: area under the receiver operating characteristic curve (AUC) and (2) calibration: observed vs predicted probability of being unable to walk independently. To improve the model predictions, we recalibrated the model containing the overall mEGOS score, without changing the individual predictive factors. Finally, we assessed the predictive ability of the individual factors. RESULTS: For validation of mEGOS at entry, 809 patients were eligible (Europe/North America [n = 677], Asia [n = 76], other [n = 56]), and 671 for validation of mEGOS at week 1 (Europe/North America [n = 563], Asia [n = 65], other [n = 43]). AUC values were >0.7 in all regional subgroups. In the Europe/North America subgroup, observed outcomes were worse than predicted; in Asia, observed outcomes were better than predicted. Recalibration improved model accuracy and enabled the development of a region-specific version for Europe/North America (mEGOS-Eu/NA). Similar to the original mEGOS, severe limb weakness and higher age were the predominant predictors of poor outcome in the IGOS cohort. DISCUSSION: mEGOS is a validated tool to predict the inability to walk unaided at 4 and 26 weeks in patients with GBS, also in countries outside the Netherlands. We developed a region-specific version of mEGOS for patients from Europe/North America. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that the mEGOS accurately predicts the inability to walk unaided at 4 and 26 weeks in patients with GBS. TRIAL REGISTRATION INFORMATION: NCT01582763.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome de Guillain-Barré Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome de Guillain-Barré Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article