Nuclear magnetic resonance reveals a two hairpin equilibrium near the 3'-splice site of influenza A segment 7 mRNA that can be shifted by oligonucleotides.

Kauffmann, Andrew D; Kennedy, Scott D; Moss, Walter N; Kierzek, Elzbieta; Kierzek, Ryszard; Turner, Douglas H

Kauffmann, Andrew D; Kennedy, Scott D; Moss, Walter N; Kierzek, Elzbieta; Kierzek, Ryszard; Turner, Douglas H.

Afiliação

Kauffmann AD; Department of Chemistry, University of Rochester, Rochester, New York 14627, USA.
Kennedy SD; Center for RNA Biology, University of Rochester, Rochester, New York 14627, USA.
Moss WN; Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.
Kierzek E; Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, USA.
Kierzek R; Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland.
Turner DH; Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland.

RNA ; 28(4): 508-522, 2022 04.

Article em En | MEDLINE | ID: mdl-34983822

Assuntos

Influenza Humana; Sítios de Splice de RNA; Sequência de Bases; Humanos; Influenza Humana/genética; Espectroscopia de Ressonância Magnética; Conformação de Ácido Nucleico; Oligonucleotídeos; Sítios de Splice de RNA/genética; RNA Mensageiro/metabolismo

Palavras-chave

NMR; hairpin target; influenza; oligonucleotide; splicing

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sítios de Splice de RNA / Influenza Humana Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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