Structural Insights into the Specificity of 8-Oxo-7,8-dihydro-2'-deoxyguanosine Bypass by Family X DNA Polymerases.

Kaminski, Andrea M; Kunkel, Thomas A; Pedersen, Lars C; Bebenek, Katarzyna

Kaminski, Andrea M; Kunkel, Thomas A; Pedersen, Lars C; Bebenek, Katarzyna.

Afiliação

Kaminski AM; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Dr., Bldg. 101, Durham, NC 27709, USA.
Kunkel TA; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Dr., Bldg. 101, Durham, NC 27709, USA.
Pedersen LC; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Dr., Bldg. 101, Durham, NC 27709, USA.
Bebenek K; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Dr., Bldg. 101, Durham, NC 27709, USA.

Genes (Basel) ; 13(1)2021 12 22.

Article em En | MEDLINE | ID: mdl-35052363

Assuntos

8-Hidroxi-2'-Desoxiguanosina/metabolismo; DNA Polimerase Dirigida por DNA/metabolismo; Domínio Catalítico/genética; DNA/genética; DNA/metabolismo; Reparo do DNA/genética; Replicação do DNA/genética; DNA Polimerase Dirigida por DNA/genética; Humanos

Palavras-chave

8-oxo-guanine (8OG); DNA repair; Family X polymerases; base excision repair (BER); nonhomologous end-joining (NHEJ); oxidized base damage

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA Polimerase Dirigida por DNA / 8-Hidroxi-2'-Desoxiguanosina Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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