Behavioural and molecular characterisation of the Dlg2 haploinsufficiency rat model of genetic risk for psychiatric disorder.

Waldron, Sophie; Pass, Rachel; Griesius, Simonas; Mellor, Jack R; Robinson, Emma S J; Thomas, Kerrie L; Wilkinson, Lawrence S; Humby, Trevor; Hall, Jeremy; Dwyer, Dominic M

Waldron, Sophie; Pass, Rachel; Griesius, Simonas; Mellor, Jack R; Robinson, Emma S J; Thomas, Kerrie L; Wilkinson, Lawrence S; Humby, Trevor; Hall, Jeremy; Dwyer, Dominic M.

Afiliação

Waldron S; School of Psychology, Cardiff University, Cardiff, UK.
Pass R; Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK.
Griesius S; Neurobiology Research Unit, Okinawa Institute of Science and Technology, Onna-son, Okinawa, Japan.
Mellor JR; Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, University Walk, Bristol, UK.
Robinson ESJ; Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, University Walk, Bristol, UK.
Thomas KL; Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, University Walk, Bristol, UK.
Wilkinson LS; Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK.
Humby T; School of Psychology, Cardiff University, Cardiff, UK.
Hall J; Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK.
Dwyer DM; School of Psychology, Cardiff University, Cardiff, UK.

Genes Brain Behav ; 21(4): e12797, 2022 04.

Article em En | MEDLINE | ID: mdl-35075790

Assuntos

Guanilato Quinases; Haploinsuficiência; Esquizofrenia; Proteínas Supressoras de Tumor; Animais; Modelos Animais de Doenças; Guanilato Quinases/genética; Humanos; Peptídeos e Proteínas de Sinalização Intracelular; Proteínas de Membrana; Camundongos; Fenciclidina/farmacologia; Ratos; Esquizofrenia/genética; Esquizofrenia/metabolismo; Comportamento Social; Proteínas Supressoras de Tumor/genética

Palavras-chave

DLG2; PCP locomotion; animal models; autism spectrum disorder; schizophrenia; sensorimotor gating; synaptic plasticity

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esquizofrenia / Proteínas Supressoras de Tumor / Guanilato Quinases / Haploinsuficiência Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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