A celebration of the 25th anniversary of chromatin-mediated spindle assembly.
Mol Biol Cell
; 33(2): rt1, 2022 02 01.
Article
em En
| MEDLINE
| ID: mdl-35076260
ABSTRACT
Formation of a bipolar spindle is required for the faithful segregation of chromosomes during cell division. Twenty-five years ago, a transformative insight into how bipolarity is achieved was provided by Rebecca Heald, Eric Karsenti, and colleagues in their landmark publication characterizing a chromatin-mediated spindle assembly pathway in which centrosomes and kinetochores were dispensable. The discovery revealed that bipolar spindle assembly is a self-organizing process where microtubules, which possess an intrinsic polarity, polymerize around chromatin and become sorted by mitotic motors into a bipolar structure. On the 25th anniversary of this seminal paper, we discuss what was known before, what we have learned since, and what may lie ahead in understanding the bipolar spindle.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cromatina
/
Montagem e Desmontagem da Cromatina
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Fuso Acromático
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article