miR-182 targeting reprograms tumor-associated macrophages and limits breast cancer progression.

Ma, Chengxin; He, Dasa; Tian, Pu; Wang, Yuan; He, Yunfei; Wu, Qiuyao; Jia, Zhenchang; Zhang, Xue; Zhang, Peiyuan; Ying, Hao; Jin, Zi-Bing; Hu, Guohong

Ma, Chengxin; He, Dasa; Tian, Pu; Wang, Yuan; He, Yunfei; Wu, Qiuyao; Jia, Zhenchang; Zhang, Xue; Zhang, Peiyuan; Ying, Hao; Jin, Zi-Bing; Hu, Guohong.

Afiliação

Ma C; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
He D; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Tian P; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Wang Y; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
He Y; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Wu Q; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Jia Z; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Zhang X; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Zhang P; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Ying H; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Jin ZB; Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing Key Lab of Ophthalmology and Visual Sciences, Beijing 100005, China.
Hu G; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China; ghhu@sibs.ac.cn.

Proc Natl Acad Sci U S A ; 119(6)2022 02 08.

Article em En | MEDLINE | ID: mdl-35105806

Assuntos

Reprogramação Celular; Neoplasias Mamárias Animais/metabolismo; MicroRNAs/metabolismo; RNA Neoplásico/metabolismo; Transdução de Sinais; Macrófagos Associados a Tumor/metabolismo; Animais; Feminino; Regulação Neoplásica da Expressão Gênica; Células HeLa; Humanos; Neoplasias Mamárias Animais/genética; Camundongos; Camundongos Knockout; MicroRNAs/genética; Proteínas de Neoplasias/genética; Proteínas de Neoplasias/metabolismo; RNA Neoplásico/genética; Receptor 4 Toll-Like/biossíntese; Receptor 4 Toll-Like/genética; Fator de Crescimento Transformador beta/biossíntese; Fator de Crescimento Transformador beta/genética

Palavras-chave

RNAi therapeutics; breast cancer; extracellular vesicle; miR-182; tumor-associated macrophage

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA Neoplásico / Transdução de Sinais / Neoplasias Mamárias Animais / MicroRNAs / Reprogramação Celular / Macrófagos Associados a Tumor Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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