Immune responses following the first dose of the Sputnik V (Gam-COVID-Vac).
Sci Rep
; 12(1): 1727, 2022 02 02.
Article
em En
| MEDLINE
| ID: mdl-35110645
ABSTRACT
As the first dose of Gam-COVID-Vac, is currently used as a single dose vaccine in some countries, we investigated the immunogenicity of this at 4 weeks (327 naïve individuals). 88.7% seroconverted, with significantly lower seroconversion rates in those over 60 years (p = 0.004) and significantly lower than previously seen with AZD1222 (p = 0.018). 82.6% developed ACE2 receptor blocking antibodies, although levels were significantly lower than following natural infection (p = 0.0009) and a single dose of AZD1222 (p < 0.0001). Similar titres of antibodies were observed to the receptor binding domain of WT, B.1.1.7 and B.1.617.2 compared to AZD1222, while the levels for B.1.351 were significantly higher (p = 0.006) for Gam-COVID-Vac. 30% developed ex vivo IFNγ ELISpot responses (significantly lower than AZD1222), and high frequency of CD107a expressing T cells along with memory B cell responses. Although single dose of Gam-COVID-Vac was highly immunogenic, administration of a second dose is likely to be beneficial.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vacinas Sintéticas
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Imunização
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Anticorpos Neutralizantes
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Imunogenicidade da Vacina
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Vacinas contra COVID-19
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SARS-CoV-2
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COVID-19
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ChAdOx1 nCoV-19
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Anticorpos Antivirais
Tipo de estudo:
Clinical_trials
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article