Presence of Tim3+ and PD-1+ CD8+ T cells identifies microsatellite stable colorectal carcinomas with immune exhaustion and distinct clinicopathological features.

Klapholz, Max; Drage, Michael G; Srivastava, Amitabh; Anderson, Ana C

Presence of Tim3⁺ and PD-1⁺ CD8⁺ T cells identifies microsatellite stable colorectal carcinomas with immune exhaustion and distinct clinicopathological features.

Klapholz, Max; Drage, Michael G; Srivastava, Amitabh; Anderson, Ana C.

Afiliação

Klapholz M; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.
Drage MG; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Srivastava A; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Anderson AC; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.

J Pathol ; 257(2): 186-197, 2022 06.

Article em En | MEDLINE | ID: mdl-35119692

Assuntos

Neoplasias Colorretais; Receptor Celular 2 do Vírus da Hepatite A; Antígeno B7-H1; Linfócitos T CD8-Positivos; Neoplasias Colorretais/genética; Neoplasias Colorretais/terapia; Receptor Celular 2 do Vírus da Hepatite A/genética; Humanos; Repetições de Microssatélites; Receptor de Morte Celular Programada 1/genética

Palavras-chave

checkpoint receptor; colorectal carcinoma; immune exhaustion; microsatellite stable

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Receptor Celular 2 do Vírus da Hepatite A Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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