Mechanistic decoupling of exonuclease III multifunctionality into AP endonuclease and exonuclease activities at the single-residue level.

Lee, Donghun; Oh, Sanghoon; Cho, HyeokJin; Yoo, Jungmin; Lee, Gwangrog

Lee, Donghun; Oh, Sanghoon; Cho, HyeokJin; Yoo, Jungmin; Lee, Gwangrog.

Afiliação

Lee D; School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Oh S; Single-Molecule Biology Laboratory, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Cho H; Cell Mechanobiology Laboratory, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Yoo J; Single-Molecule Biology Laboratory, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Lee G; Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.

Nucleic Acids Res ; 50(4): 2211-2222, 2022 02 28.

Article em En | MEDLINE | ID: mdl-35137198

Assuntos

DNA Liase (Sítios Apurínicos ou Apirimidínicos); Endonucleases; Aminoácidos/genética; Reparo do DNA; DNA Liase (Sítios Apurínicos ou Apirimidínicos)/metabolismo; Endonucleases/metabolismo; Exodesoxirribonucleases/metabolismo; Modelos Moleculares; Enzimas Multifuncionais/genética; Fosfodiesterase I/genética; Especificidade por Substrato

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA Liase (Sítios Apurínicos ou Apirimidínicos) / Endonucleases Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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