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The PAX5-JAK2 translocation acts as dual-hit mutation that promotes aggressive B-cell leukemia via nuclear STAT5 activation.
Jurado, Sabine; Fedl, Anna S; Jaritz, Markus; Kostanova-Poliakova, Daniela; Malin, Stephen G; Mullighan, Charles G; Strehl, Sabine; Fischer, Maria; Busslinger, Meinrad.
Afiliação
  • Jurado S; Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
  • Fedl AS; Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
  • Jaritz M; Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
  • Kostanova-Poliakova D; Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
  • Malin SG; Laboratory of Immunobiology, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden.
  • Mullighan CG; Department of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA.
  • Strehl S; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.
  • Fischer M; Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
  • Busslinger M; Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
EMBO J ; 41(7): e108397, 2022 04 04.
Article em En | MEDLINE | ID: mdl-35156727
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia de Células B / Fator de Transcrição STAT5 / Fator de Transcrição PAX5 / Janus Quinase 2 Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia de Células B / Fator de Transcrição STAT5 / Fator de Transcrição PAX5 / Janus Quinase 2 Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article