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Silent mutations reveal therapeutic vulnerability in RAS Q61 cancers.
Kobayashi, Yoshihisa; Chhoeu, Chhayheng; Li, Jiaqi; Price, Kristin S; Kiedrowski, Lesli A; Hutchins, Jamie L; Hardin, Aaron I; Wei, Zihan; Hong, Fangxin; Bahcall, Magda; Gokhale, Prafulla C; Jänne, Pasi A.
Afiliação
  • Kobayashi Y; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. yoshikob@ncc.go.jp.
  • Chhoeu C; Department of Medicine, Harvard Medical School, Boston, MA, USA. yoshikob@ncc.go.jp.
  • Li J; Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan. yoshikob@ncc.go.jp.
  • Price KS; Experimental Therapeutics Core, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Kiedrowski LA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Hutchins JL; Department of Medical Affairs, Guardant Health, Redwood City, CA, USA.
  • Hardin AI; Department of Medical Affairs, Guardant Health, Redwood City, CA, USA.
  • Wei Z; Department of Medical Affairs, Guardant Health, Redwood City, CA, USA.
  • Hong F; Department of Medical Affairs, Guardant Health, Redwood City, CA, USA.
  • Bahcall M; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Gokhale PC; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Jänne PA; Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Nature ; 603(7900): 335-342, 2022 03.
Article em En | MEDLINE | ID: mdl-35236983
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas p21(ras) / Mutação Silenciosa / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas p21(ras) / Mutação Silenciosa / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article