Use of Autologous Serum Eye Drops with Contact Lenses in the Treatment of Chemical Burn-Induced Bilateral Corneal Persistent Epithelial Defects.
Biomed Res Int
; 2022: 6600788, 2022.
Article
em En
| MEDLINE
| ID: mdl-35237689
ABSTRACT
OBJECTIVE:
We aim to evaluate the clinical effect of combined topical 20% autologous serum eye drops (ASEs) along with silicone-hydrogel soft contact lenses (SCLs) in the treatment of chemical burn-induced bilateral corneal persistent epithelial defects (PEDs) and to review the literature of related studies.METHODS:
From January 1, 2017, to December 31, 2019, we conducted a retrospective chart review of 8 patients with chemical burn-induced bilateral corneal PEDs who were unsuccessfully treated with conventional medical therapy and were then treated with combined topical 20% (v/v) ASEs and silicone-hydrogel CLs. The clinical effects and effectiveness of the combined treatment were evaluated.RESULTS:
The bilateral corneal PEDs healed in all sixteen eyes of the eight patients within 2 weeks. The patients did not report any discomfort associated with the combined treatment. Improved ocular comfort/visual acuity and decreased conjunctival injection correlated with healing. No recurrent corneal epithelial breakdown was noted during the 3-month posttreatment follow-up.CONCLUSIONS:
The combined treatment of silicone-hydrogel CLs and ASEs can help to stabilize the ocular surface and successfully treat chemical burn-induced bilateral corneal PEDs. It may be considered as an alternative treatment method for patients with bilateral chemical burn-induced corneal PEDs with potential corneal melting.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Soluções Oftálmicas
/
Cicatrização
/
Queimaduras Químicas
/
Doenças da Córnea
Tipo de estudo:
Etiology_studies
Limite:
Adult
/
Humans
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Male
/
Middle aged
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article