In Vitro Determination of Inhibitory Effects of Humic Substances Complexing Zn and Se on SARS-CoV-2 Virus Replication.

Hajdrik, Polett; Pályi, Bernadett; Kis, Zoltán; Kovács, Noémi; Veres, Dániel Sándor; Szigeti, Krisztián; Budán, Ferenc; Hegedüs, Imre; Kovács, Tibor; Bergmann, Ralf; Máthé, Domokos.

Afiliação

Hajdrik P; Department of Biophysics and Radiation Biology, Semmelweis University, Ülloi út 26., H-1085 Budapest, Hungary.
Pályi B; National Biosafety Laboratory, National Public Health Center, Albert Flórián út 2-6, H-1097 Budapest, Hungary.
Kis Z; National Biosafety Laboratory, National Public Health Center, Albert Flórián út 2-6, H-1097 Budapest, Hungary.
Kovács N; Department of Microbiology, Semmelweis University, Ülloi út 26., H-1085 Budapest, Hungary.
Veres DS; Department of Biophysics and Radiation Biology, Semmelweis University, Ülloi út 26., H-1085 Budapest, Hungary.
Szigeti K; CROmed Translational Research Ltd., Tuzoltó u. 37-47, H-1094 Budapest, Hungary.
Budán F; Department of Biophysics and Radiation Biology, Semmelweis University, Ülloi út 26., H-1085 Budapest, Hungary.
Hegedüs I; Department of Biophysics and Radiation Biology, Semmelweis University, Ülloi út 26., H-1085 Budapest, Hungary.
Kovács T; Institute of Transdisciplinary Discoveries, Medical School, University of Pécs, Ifjúság útja 11, H-7624 Pécs, Hungary.
Bergmann R; Institute of Physiology, Medical School, University of Pécs, Szigeti út 12, H-7624 Pécs, Hungary.
Máthé D; Department of Biophysics and Radiation Biology, Semmelweis University, Ülloi út 26., H-1085 Budapest, Hungary.

Foods ; 11(5)2022 Feb 26.

Article em En | MEDLINE | ID: mdl-35267328

ABSTRACT

(1)

Background:

Humic substances are well-known human nutritional supplement materials and they play an important performance-enhancing role as animal feed additives. For decades, ingredients of humic substances have been proven to carry potent antiviral effects against different viruses. (2)

Here, the antiviral activity of a humic substance containing ascorbic acid, Se- and Zn2+ ions intended as a nutritional supplement material was investigated against SARS-CoV-2 virus B1.1.7 Variant of Concern ("Alpha Variant") in a VeroE6 cell line. (3)

This combination has a significant in vitro antiviral effect at a very low concentration range of its intended active ingredients. (4)

Even picomolar concentration ranges of humic substances, Vitamin C and Zn/Se ions in the given composition, were enough to achieve 50% viral replication inhibition in the applied SARS-CoV-2 virus inhibition test.

Palavras-chave

RT-PCR; SARS-CoV-2; Zn-Se-ascorbic acid complex; antiviral activity; fulvic acid; humic acid

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article