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Is hypoimmunogenic stem cell therapy safe in times of pandemics?
Matheus, Friederike; Raveh, Tal; Oro, Anthony E; Wernig, Marius; Drukker, Micha.
Afiliação
  • Matheus F; Institute for Stem Cell Research, iPSC Core Facility, Helmholtz Zentrum München GmbH, 85764 Neuherberg, Germany.
  • Raveh T; Institute for Stem Cell Biology and Regenerative Medicine, and Ludwig Center for Cancer Stem Cell Research, Stanford University School of Medicine, Stanford, CA, USA.
  • Oro AE; Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Wernig M; Institute for Stem Cell Biology and Regenerative Medicine and Department of Pathology, Stanford University Medical School, Stanford, CA 94305, USA.
  • Drukker M; Institute for Stem Cell Research, iPSC Core Facility, Helmholtz Zentrum München GmbH, 85764 Neuherberg, Germany; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, 2333 CC RA Leiden, The Netherlands. Electronic address: m.drukker@lacdr.leidenu
Stem Cell Reports ; 17(4): 711-714, 2022 04 12.
Article em En | MEDLINE | ID: mdl-35334219
ABSTRACT
The manipulation of human leukocyte antigens (HLAs) and immune modulatory factors in "universal" human pluripotent stem cells (PSCs) holds promise for immunological tolerance without HLA matching. This paradigm raises concerns should "universal" grafts become virally infected. Furthermore, immunological manipulation might functionally impair certain progeny, such as hematopoietic stem cells. We discuss the risks and benefits of hypoimmunogenic PSCs, and the need to further advance HLA matching and autologous strategies.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Pluripotentes / Pandemias Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Pluripotentes / Pandemias Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article