Is hypoimmunogenic stem cell therapy safe in times of pandemics?
Stem Cell Reports
; 17(4): 711-714, 2022 04 12.
Article
em En
| MEDLINE
| ID: mdl-35334219
ABSTRACT
The manipulation of human leukocyte antigens (HLAs) and immune modulatory factors in "universal" human pluripotent stem cells (PSCs) holds promise for immunological tolerance without HLA matching. This paradigm raises concerns should "universal" grafts become virally infected. Furthermore, immunological manipulation might functionally impair certain progeny, such as hematopoietic stem cells. We discuss the risks and benefits of hypoimmunogenic PSCs, and the need to further advance HLA matching and autologous strategies.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Pluripotentes
/
Pandemias
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article