Protective effect of flavonoids extract of Hippophae rhamnoides L. on alcoholic fatty liver disease through regulating intestinal flora and inhibiting TAK1/p38MAPK/p65NF-&#954;B pathway.

Zhao, Hong; Kong, Lingzhou; Shao, Mengting; Liu, Jiayue; Sun, Changhai; Li, Changxu; Wang, Yanyan; Chai, Xue; Wang, Yuliang; Zhang, Yu; Li, Xiaoliang

Protective effect of flavonoids extract of Hippophae rhamnoides L. on alcoholic fatty liver disease through regulating intestinal flora and inhibiting TAK1/p38MAPK/p65NF-κB pathway.

Zhao, Hong; Kong, Lingzhou; Shao, Mengting; Liu, Jiayue; Sun, Changhai; Li, Changxu; Wang, Yanyan; Chai, Xue; Wang, Yuliang; Zhang, Yu; Li, Xiaoliang.

Afiliação

Zhao H; College of Pharmacy, Jiamusi University, Jiamusi, 154007, Heilongjiang, PR China.
Kong L; College of Pharmacy, Jiamusi University, Jiamusi, 154007, Heilongjiang, PR China.
Shao M; College of Pharmacy, Jiamusi University, Jiamusi, 154007, Heilongjiang, PR China.
Liu J; College of Pharmacy, Jiamusi University, Jiamusi, 154007, Heilongjiang, PR China.
Sun C; College of Pharmacy, Jiamusi University, Jiamusi, 154007, Heilongjiang, PR China.
Li C; College of Pharmacy, Jiamusi University, Jiamusi, 154007, Heilongjiang, PR China.
Wang Y; College of Pharmacy, Jiamusi University, Jiamusi, 154007, Heilongjiang, PR China.
Chai X; College of Pharmacy, Jiamusi University, Jiamusi, 154007, Heilongjiang, PR China.
Wang Y; College of Pharmacy, Jiamusi University, Jiamusi, 154007, Heilongjiang, PR China.
Zhang Y; College of Pharmacy, Jiamusi University, Jiamusi, 154007, Heilongjiang, PR China.
Li X; College of Pharmacy, Jiamusi University, Jiamusi, 154007, Heilongjiang, PR China; Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs, Haikou Key Laboratory of Li Nationality Medicine, School of P

J Ethnopharmacol ; 292: 115225, 2022 Jun 28.

Article em En | MEDLINE | ID: mdl-35341932

Assuntos

Fígado Gorduroso Alcoólico; Microbioma Gastrointestinal; Hippophae; Animais; Ecossistema; Fígado Gorduroso Alcoólico/tratamento farmacológico; Fígado Gorduroso Alcoólico/metabolismo; Flavonoides/metabolismo; Flavonoides/farmacologia; Flavonoides/uso terapêutico; Hippophae/química; Fígado; Camundongos; Extratos Vegetais/química; Extratos Vegetais/farmacologia; Extratos Vegetais/uso terapêutico; RNA Ribossômico 16S/genética; Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo

Palavras-chave

Alcoholic fatty liver disease; Flavone; Hepatoprotective; Hippophae rhamnoides L; Intestinal microbiota; Sea buckthorn

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hippophae / Fígado Gorduroso Alcoólico / Microbioma Gastrointestinal Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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