Copper-Catalyzed Oxidative Coupling of Quinazoline-3-Oxides: Synthesis of O-Quinazolinic Carbamates.
J Org Chem
; 87(8): 5136-5148, 2022 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-35349287
ABSTRACT
Organic carbamates represent a kind of privileged structures in both organic chemistry and industry. Despite the fact that the synthesis of alcohol-based carbamates has been well studied, an efficient access to hydroxamic acid-based carbamates is less explored due to the nucleophilicity of both O and N atoms in hydroxamic acids. Herein, we report a copper-catalyzed oxidative coupling of quinazoline-3-oxides and formamides for the synthesis of O-quinazolinic carbamates. This protocol is featured with practicability, simple starting materials, and operational simplicity.
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Base de dados:
MEDLINE
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Guideline
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article