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A benzodiazepine activator locks Kv7.1 channels open by electro-mechanical uncoupling.
Schreiber, Julian A; Möller, Melina; Zaydman, Mark; Zhao, Lu; Beller, Zachary; Becker, Sebastian; Ritter, Nadine; Hou, Panpan; Shi, Jingyi; Silva, Jon; Wrobel, Eva; Strutz-Seebohm, Nathalie; Decher, Niels; Schmitt, Nicole; Meuth, Sven G; Düfer, Martina; Wünsch, Bernhard; Cui, Jianmin; Seebohm, Guiscard.
Afiliação
  • Schreiber JA; Institute for Genetics of Heart Diseases (IfGH), Department of Cardiovascular Medicine, University Hospital Münster, D-48149, Münster, Germany.
  • Möller M; Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Corrensstr. 48, Münster, D-48149, Germany.
  • Zaydman M; Institute for Genetics of Heart Diseases (IfGH), Department of Cardiovascular Medicine, University Hospital Münster, D-48149, Münster, Germany.
  • Zhao L; Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, MO, 63130, USA.
  • Beller Z; Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, MO, 63130, USA.
  • Becker S; Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, MO, 63130, USA.
  • Ritter N; Institute for Genetics of Heart Diseases (IfGH), Department of Cardiovascular Medicine, University Hospital Münster, D-48149, Münster, Germany.
  • Hou P; Institute for Genetics of Heart Diseases (IfGH), Department of Cardiovascular Medicine, University Hospital Münster, D-48149, Münster, Germany.
  • Shi J; Chembion, University of Münster, D-48149, Münster, Germany.
  • Silva J; Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, MO, 63130, USA.
  • Wrobel E; Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, MO, 63130, USA.
  • Strutz-Seebohm N; Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, MO, 63130, USA.
  • Decher N; Institute for Genetics of Heart Diseases (IfGH), Department of Cardiovascular Medicine, University Hospital Münster, D-48149, Münster, Germany.
  • Schmitt N; Institute for Genetics of Heart Diseases (IfGH), Department of Cardiovascular Medicine, University Hospital Münster, D-48149, Münster, Germany.
  • Meuth SG; Institute of Physiology and Pathophysiology, Vegetative Physiology, Philipps-University of Marburg, Deutschhausstr. 1-2, 35037, Marburg, Germany.
  • Düfer M; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Wünsch B; Department of Neurology, University Hospital Düsseldorf, Düsseldorf, Germany.
  • Cui J; Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Corrensstr. 48, Münster, D-48149, Germany.
  • Seebohm G; Chembion, University of Münster, D-48149, Münster, Germany.
Commun Biol ; 5(1): 301, 2022 04 01.
Article em En | MEDLINE | ID: mdl-35365746
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzodiazepinas / Ativação do Canal Iônico Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzodiazepinas / Ativação do Canal Iônico Idioma: En Ano de publicação: 2022 Tipo de documento: Article