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Establishment of baseline profiles of 50 bile acids in preclinical toxicity species: A comprehensive assessment of translational differences and study design considerations for biomarker development.
Sangaraju, Dewakar; Katavolos, Paula; Liang, Xiaorong; Chou, Carolina; Zabka, Tanja S; Dean, Brian; Maher, Jonathan.
Afiliação
  • Sangaraju D; Drug Metabolism & Pharmacokinetics, Genentech, Inc., South San Francisco, CA, United States of America. Electronic address: sangaraju.dewakar@gene.com.
  • Katavolos P; Nonclinical Safety, Bristol Myers Squibb, New Brunswick, NJ, United States of America.
  • Liang X; Drug Metabolism & Pharmacokinetics, Genentech, Inc., South San Francisco, CA, United States of America.
  • Chou C; Safety Assessment, Genentech, Inc., Translational Safety Sciences, United States of America.
  • Zabka TS; Safety Assessment, Genentech, Inc., Translational Safety Sciences, United States of America.
  • Dean B; Drug Metabolism & Pharmacokinetics, Genentech, Inc., South San Francisco, CA, United States of America.
  • Maher J; Theravance, South San Francisco, CA, United States of America.
Toxicol Appl Pharmacol ; 443: 116008, 2022 05 15.
Article em En | MEDLINE | ID: mdl-35378153
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácidos e Sais Biliares / Doença Hepática Induzida por Substâncias e Drogas Tipo de estudo: Guideline Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácidos e Sais Biliares / Doença Hepática Induzida por Substâncias e Drogas Tipo de estudo: Guideline Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article