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Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain-a Game Changing Parameter for CNS Drug Discovery and Development.
Loryan, Irena; Reichel, Andreas; Feng, Bo; Bundgaard, Christoffer; Shaffer, Christopher; Kalvass, Cory; Bednarczyk, Dallas; Morrison, Denise; Lesuisse, Dominique; Hoppe, Edmund; Terstappen, Georg C; Fischer, Holger; Di, Li; Colclough, Nicola; Summerfield, Scott; Buckley, Stephen T; Maurer, Tristan S; Fridén, Markus.
Afiliação
  • Loryan I; Department of Pharmacy, Uppsala University, Box 580, Uppsala, Sweden. irena.loryan@farmaci.uu.se.
  • Reichel A; DMPK M&S, Pharma R&D, Bayer AG, Berlin, Germany.
  • Feng B; DMPK, Vertex Pharmaceuticals, Boston, Massachusetts, 02210, USA.
  • Bundgaard C; Translational DMPK, H. Lundbeck A/S, Copenhagen, Denmark.
  • Shaffer C; External Innovation, Research & Development, Biogen Inc., Cambridge, Massachusetts, USA.
  • Kalvass C; DMPK-BA, AbbVie, Inc., North Chicago, Illinois, USA.
  • Bednarczyk D; Pharmacokinetic Sciences, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
  • Morrison D; DMPK, Janssen Research & Development, Beerse, Belgium.
  • Lesuisse D; Rare and Neurological Diseases, Sanofi, Chilly Mazarin, France.
  • Hoppe E; DMPK, Boehringer-Ingelheim Pharma GmbH & Co. KG, Biberach, Germany.
  • Terstappen GC; Cambrian Biopharma, New York, New York, USA.
  • Fischer H; Translational PK/PD and Clinical Pharmacology, Pharmaceutical Sciences, Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland.
  • Di L; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, USA.
  • Colclough N; Oncology DMPK, Oncology R&D, AstraZeneca, Cambridge, UK.
  • Summerfield S; Bioanalysis Immunogenicity and Biomarkers, GSK, Gunnels Wood Road, Stevenage, SG1 2NY, Hertfordshire, UK.
  • Buckley ST; Global Research Technologies, Novo Nordisk A/S, Måløv, Denmark.
  • Maurer TS; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, USA.
  • Fridén M; Department of Pharmacy, Uppsala University, Box 580, Uppsala, Sweden.
Pharm Res ; 39(7): 1321-1341, 2022 Jul.
Article em En | MEDLINE | ID: mdl-35411506
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Barreira Hematoencefálica / Fármacos do Sistema Nervoso Central / Descoberta de Drogas Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Barreira Hematoencefálica / Fármacos do Sistema Nervoso Central / Descoberta de Drogas Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article