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The small HDL particle hypothesis of Alzheimer's disease.
Martinez, Ashley E; Weissberger, Gali; Kuklenyik, Zsuzsanna; He, Xulei; Meuret, Cristiana; Parekh, Trusha; Rees, Jon C; Parks, Bryan A; Gardner, Michael S; King, Sarah M; Collier, Timothy S; Harrington, Michael G; Sweeney, Melanie D; Wang, Xinhui; Zlokovic, Berislav V; Joe, Elizabeth; Nation, Daniel A; Schneider, Lon S; Chui, Helena C; Barr, John R; Han, S Duke; Krauss, Ronald M; Yassine, Hussein N.
Afiliação
  • Martinez AE; Department of Medicine, University of Southern California, Los Angeles, California, USA.
  • Weissberger G; The Interdisciplinary Department of Social Sciences, Bar Ilan University, Israel.
  • Kuklenyik Z; Clinical Chemistry Branch, Division of Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • He X; Department of Medicine, University of Southern California, Los Angeles, California, USA.
  • Meuret C; Department of Medicine, University of Southern California, Los Angeles, California, USA.
  • Parekh T; Department of Medicine, University of Southern California, Los Angeles, California, USA.
  • Rees JC; Clinical Chemistry Branch, Division of Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Parks BA; Clinical Chemistry Branch, Division of Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Gardner MS; Clinical Chemistry Branch, Division of Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • King SM; Departments of Pediatrics and Medicine, University of California, San Francisco, California, USA.
  • Collier TS; Quest Diagnostics, Cleveland HeartLab, Cleveland, Ohio, USA.
  • Harrington MG; Department of Neurology, University of Southern California, Los Angeles, California, USA.
  • Sweeney MD; Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California, USA.
  • Wang X; Department of Neurology, University of Southern California, Los Angeles, California, USA.
  • Zlokovic BV; Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California, USA.
  • Joe E; Department of Neurology, University of Southern California, Los Angeles, California, USA.
  • Nation DA; Irvine, Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
  • Schneider LS; Department of Neurology, University of Southern California, Los Angeles, California, USA.
  • Chui HC; Department of Psychiatry and Behavioral Sciences, University of Southern California, Los Angeles, California, USA.
  • Barr JR; Department of Neurology, University of Southern California, Los Angeles, California, USA.
  • Han SD; Clinical Chemistry Branch, Division of Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Krauss RM; Department of Family Medicine, University of Southern California, Los Angeles, California, USA.
  • Yassine HN; Departments of Pediatrics and Medicine, University of California, San Francisco, California, USA.
Alzheimers Dement ; 19(2): 391-404, 2023 02.
Article em En | MEDLINE | ID: mdl-35416404
ABSTRACT
We propose the hypothesis that small high-density lipoprotein (HDL) particles reduce the risk of Alzheimer's disease (AD) by virtue of their capacity to exchange lipids, affecting neuronal membrane composition and vascular and synaptic functions. Concentrations of small HDLs in cerebrospinal fluid (CSF) and plasma were measured in 180 individuals ≥60 years of age using ion mobility methodology. Small HDL concentrations in CSF were positively associated with performance in three domains of cognitive function independent of apolipoprotein E (APOE) ε4 status, age, sex, and years of education. Moreover, there was a significant correlation between levels of small HDLs in CSF and plasma. Further studies will be aimed at determining whether specific components of small HDL exchange across the blood, brain, and CSF barriers, and developing approaches to exploit small HDLs for therapeutic purposes.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article