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Dormann, Dorothee; Behrends, Christian

Dormann, Dorothee; Behrends, Christian.

Afiliação

Dormann D; Johannes Gutenberg University (JGU) Mainz, Faculty of Biology, Institute of Molecular Physiology, Mainz, Germany; Institute of Molecular Biology (IMB) Mainz, Mainz, Germany. Electronic address: ddormann@uni-mainz.de.
Behrends C; Munich Cluster for Systems Neurology (SyNergy), Medical Faculty, Ludwig-Maximilians-University München, Munich, Germany. Electronic address: christian.behrends@mail03.med.uni-muenchen.de.

Mol Cell ; 82(8): 1408-1410, 2022 04 21.

Article em En | MEDLINE | ID: mdl-35452612

ABSTRACT

ABSTRACT

To elucidate the mechanism driving selective autophagy of protein aggregates, or "aggrephagy," Ma et al. (2022) identify chaperonin TRiC subunit CCT2 as a receptor that specifically promotes the clearance of solid aggregates, but not liquid-like condensates, in a ubiquitin-independent manner.

Assuntos

Resíduos Sólidos; Ubiquitina; Autofagia; Proteínas de Transporte/metabolismo; Agregados Proteicos; Ubiquitina/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Resíduos Sólidos / Ubiquitina Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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