Influence of the Type of Amino Acid on the Permeability and Properties of Ibuprofenates of Isopropyl Amino Acid Esters.
Int J Mol Sci
; 23(8)2022 Apr 09.
Article
em En
| MEDLINE
| ID: mdl-35456976
ABSTRACT
Modifications of (RS)-2-[4-(2-methylpropyl)phenyl] propanoic acid with amino acid isopropyl esters were synthesised using different methods via a common intermediate. The main reaction was the esterification of the carboxyl group of amino acids with isopropanol and chlorination of the amino group of the amino acid, followed by an exchange or neutralisation reaction and protonation. All of the proposed methods were very efficient, and the compounds obtained have great potential to be more effective drugs with increased skin permeability compared with ibuprofen. In addition, it was shown how the introduction of a modification in the form of an ion pair affects the properties of the obtained compound.
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MEDLINE
Assunto principal:
Absorção Cutânea
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Ésteres
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article