Recent thymic emigrants as the bridge between thymoma and autoimmune diseases.
Biochim Biophys Acta Rev Cancer
; 1877(3): 188730, 2022 05.
Article
em En
| MEDLINE
| ID: mdl-35469968
ABSTRACT
Recent thymic emigrants (RTEs) are naïve T cells that egress the thymus following intrathymic development. This continuous process, including self-renewal, is crucial to establish and maintain human immune function. Several biomarkers can identify RTEs, but none of them is specific. Additional methods to detect and study RTEs phenotypically and functionally revealed alterations in RTEs in various adverse health conditions, including autoimmune diseases, systemic disorders and thymic abnormalities such as thymoma. Often associated with autoimmune disease, thymoma is the only tumor that can generate RTEs. However, a causal relationship between RTEs and autoimmune disease remains uncertain. Here, we review current knowledge about the connections between thymoma, RTEs and autoimmune diseases to provide new perspectives for therapeutic strategies.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
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Timoma
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Neoplasias do Timo
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article