Physicochemical classification of organisms.
Proc Natl Acad Sci U S A
; 119(19): e2122957119, 2022 05 10.
Article
em En
| MEDLINE
| ID: mdl-35500111
ABSTRACT
The hypervariable residues that compose the major part of proteins' surfaces are generally considered outside evolutionary control. Yet, these "nonconserved" residues determine the outcome of stochastic encounters in crowded cells. It has recently become apparent that these encounters are not as random as one might imagine, but carefully orchestrated by the intracellular electrostatics to optimize protein diffusion, interactivity, and partner search. The most influential factor here is the protein surface-charge density, which takes different optimal values across organisms with different intracellular conditions. In this study, we examine how far the net-charge density and other physicochemical properties of proteomes will take us in terms of distinguishing organisms in general. The results show that these global proteome properties not only follow the established taxonomical hierarchy, but also provide clues to functional adaptation. In many cases, the proteomeproperty divergence is even resolved at species level. Accordingly, the variable parts of the genes are not as free to drift as they seem in sequence alignment, but present a complementary tool for functional, taxonomic, and evolutionary assignment.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Filogenia
/
Proteínas
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Alinhamento de Sequência
Limite:
Animals
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article