Cobalt-catalyzed tandem one-pot synthesis of polysubstituted imidazo[1,5-a]pyridines and imidazo[1,5-a]isoquinolines.
Org Biomol Chem
; 20(20): 4215-4223, 2022 05 26.
Article
em En
| MEDLINE
| ID: mdl-35546113
ABSTRACT
An efficient cobalt-catalyzed tandem one-pot method has been developed for the synthesis of polysubstituted imidazo[1,5-a]-N-heteroaromatics. The method involves Knoevenagel condensation followed by cobalt-catalyzed direct alkenylation to give the desired polysubstituted imidazo[1,5-a]pyridines and imidazo[1,5-a]isoquinolines in a one-pot manner. This method exhibits a broad substrate scope, provides moderate to good (39-74%) yields and is amenable to scale-up to the gram scale.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Isoquinolinas
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article