The evolution of gene regulation on sex chromosomes.
Trends Genet
; 38(8): 844-855, 2022 08.
Article
em En
| MEDLINE
| ID: mdl-35577641
ABSTRACT
Sex chromosomes have evolved repeatedly across the tree of life. Most work has focused on the loss of coding regions from sex-limited chromosomes through the accumulation of deleterious mutations. By comparison, less is known about how the regulatory landscape evolves. We review theories of how regulatory landscapes evolve on sex chromosomes and the overall impact they have on gametolog expression. We integrate empirical studies on sex chromosomes with theoretical work to synthesize how regulatory evolution could occur on sex chromosomes. Recent findings have revealed that downregulation of ancestral alleles is probably widespread on Y chromosomes and that regulatory evolution plays a key role in the evolution of sex chromosomes.
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Base de dados:
MEDLINE
Assunto principal:
Cromossomos Sexuais
/
Evolução Molecular
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article