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Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1Q.
Spurrier, Joshua; Nicholson, LaShae; Fang, Xiaotian T; Stoner, Austin J; Toyonaga, Takuya; Holden, Daniel; Siegert, Timothy R; Laird, William; Allnutt, Mary Alice; Chiasseu, Marius; Brody, A Harrison; Takahashi, Hideyuki; Nies, Sarah Helena; Pérez-Cañamás, Azucena; Sadasivam, Pragalath; Lee, Supum; Li, Songye; Zhang, Le; Huang, Yiyun H; Carson, Richard E; Cai, Zhengxin; Strittmatter, Stephen M.
Afiliação
  • Spurrier J; Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA.
  • Nicholson L; Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA.
  • Fang XT; Yale PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT 06510, USA.
  • Stoner AJ; Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA.
  • Toyonaga T; Yale PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT 06510, USA.
  • Holden D; Yale PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT 06510, USA.
  • Siegert TR; Allyx Therapeutics Inc., New Haven, CT 06513, USA.
  • Laird W; Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA.
  • Allnutt MA; Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA.
  • Chiasseu M; Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA.
  • Brody AH; Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA.
  • Takahashi H; Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA.
  • Nies SH; Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA.
  • Pérez-Cañamás A; Graduate School of Cellular and Molecular Neuroscience, University of Tübingen, Tübingen 72074, Germany.
  • Sadasivam P; Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA.
  • Lee S; Yale PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT 06510, USA.
  • Li S; Yale PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT 06510, USA.
  • Zhang L; Yale PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT 06510, USA.
  • Huang YH; Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA.
  • Carson RE; Yale PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT 06510, USA.
  • Cai Z; Yale PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT 06510, USA.
  • Strittmatter SM; Yale PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT 06510, USA.
Sci Transl Med ; 14(647): eabi8593, 2022 06.
Article em En | MEDLINE | ID: mdl-35648810
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Receptor de Glutamato Metabotrópico 5 Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Receptor de Glutamato Metabotrópico 5 Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article