CXCL4 synergizes with TLR8 for TBK1-IRF5 activation, epigenomic remodeling and inflammatory response in human monocytes.

Yang, Chao; Bachu, Mahesh; Du, Yong; Brauner, Caroline; Yuan, Ruoxi; Ah Kioon, Marie Dominique; Chesi, Giancarlo; Barrat, Franck J; Ivashkiv, Lionel B

Yang, Chao; Bachu, Mahesh; Du, Yong; Brauner, Caroline; Yuan, Ruoxi; Ah Kioon, Marie Dominique; Chesi, Giancarlo; Barrat, Franck J; Ivashkiv, Lionel B.

Afiliação

Yang C; HSS Research Institute and David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, USA.
Bachu M; HSS Research Institute and David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, USA.
Du Y; HSS Research Institute and David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, USA.
Brauner C; HSS Research Institute and David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, USA.
Yuan R; HSS Research Institute and David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, USA.
Ah Kioon MD; HSS Research Institute and David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, USA.
Chesi G; HSS Research Institute and David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, USA.
Barrat FJ; HSS Research Institute and David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, USA.
Ivashkiv LB; Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, New York, NY, USA.

Nat Commun ; 13(1): 3426, 2022 06 14.

Article em En | MEDLINE | ID: mdl-35701499

Assuntos

Quinase I-kappa B; Fatores Reguladores de Interferon; Monócitos; Fator Plaquetário 4; Proteínas Serina-Treonina Quinases; Receptor 8 Toll-Like; Epigênese Genética; Humanos; Quinase I-kappa B/genética; Quinase I-kappa B/imunologia; Quinase I-kappa B/metabolismo; Inflamação/genética; Inflamação/imunologia; Inflamação/metabolismo; Fatores Reguladores de Interferon/genética; Fatores Reguladores de Interferon/imunologia; Fatores Reguladores de Interferon/metabolismo; Macrófagos/imunologia; Macrófagos/metabolismo; Monócitos/imunologia; Monócitos/metabolismo; Fator Plaquetário 4/imunologia; Fator Plaquetário 4/metabolismo; Proteínas Serina-Treonina Quinases/genética; Proteínas Serina-Treonina Quinases/imunologia; Proteínas Serina-Treonina Quinases/metabolismo; Receptor 8 Toll-Like/genética; Receptor 8 Toll-Like/imunologia; Receptor 8 Toll-Like/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator Plaquetário 4 / Monócitos / Proteínas Serina-Treonina Quinases / Quinase I-kappa B / Fatores Reguladores de Interferon / Receptor 8 Toll-Like Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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