4HNE, 4-hydroxynonenal; CV, central vein; ECM, extracellular matrix; ETC, electron transfer chain; GSH, reduced glutathione (glutathione); GSSG, oxidized glutathione (glutathione disulfide); HSCs, hepatic stellate cells; IGRT, image-guided radiation therapy; IHC, immunohistochemistry; IMC, imaging mass cytometry; MDA, malondialdehyde; RILD, radiation-induced liver disease; RNAseq, RNA sequencing; ROS; ROS, reactive oxygen species; RT, radiation therapy; SASP, senescence-associated secretory phenotype; SNP, single nucleotide polymorphism; SOS, sinusoidal obstruction syndrome; fibrosis; image guided radiation therapy (IGRT); mitochondrial dysfunction; mitochondrial-DNA; mouse model; mtDNA, mitochondrial DNA; mtROS, mitochondrial reactive oxygen species; p53; radiation-induced liver disease (RILD); rcf, relative centrifuge force; senescence; sinusoidal obstruction syndrome