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Effects of probiotic Lactiplantibacillus plantarum IMC 510 supplementation on metabolic factors in otherwise healthy overweight and obese individuals.
Coman, Maria Magdalena; Miorelli, Lorenzo; Micioni Di Bonaventura, Maria Vittoria; Cifani, Carlo; Salvesi, Chiara; Amedei, Amedeo; Silvi, Stefania; Verdenelli, Maria Cristina.
Afiliação
  • Coman MM; Synbiotec S.r.l., Spin-off of UNICAM, Camerino, Italy.
  • Miorelli L; Sacco System S.r.l., Zelo Buon Persico, Lodi, Italy.
  • Micioni Di Bonaventura MV; Pharmacology Unit, School of Pharmacy, University of Camerino, Camerino, Italy.
  • Cifani C; Pharmacology Unit, School of Pharmacy, University of Camerino, Camerino, Italy.
  • Salvesi C; School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy.
  • Amedei A; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Silvi S; School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy.
  • Verdenelli MC; Synbiotec S.r.l., Spin-off of UNICAM, Camerino, Italy.
J Appl Microbiol ; 133(3): 1956-1968, 2022 Sep.
Article em En | MEDLINE | ID: mdl-35796632
AIMS: Probiotic supplementation approach offers the possibility to shape the gut microbiota (GM), enabling the development of innovative formulations able to improve intestinal well-being and consequently the related body weight modulation and energy metabolism. In the present clinical study, a new potential probiotic supplement based on Lactiplantibacillus plantarum IMC 510 was studied for weight management. METHODS AND RESULTS: Quantitative characterization by qPCR of representative bacterial groups of GM was used to determine the microbiota modulation at different supplementation periods. Furthermore, measurement of the endpoints linked to weight control (body mass index, body weight, waist circumference) was assessed. Specific questionnaires to evaluate the impact on psychological and physiological point of view were performed. Results showed that after 90 days, Lact. plantarum IMC 510 supplementation brought an improvement in endpoints linked to weight control and healthy status, although no significant changes in the microbiota composition were reported for analysed bacterial groups, except for Lactobacillus spp. and Bifidobacterium spp. CONCLUSIONS: We concluded that Lact. plantarum IMC 510 supplementation could be an interesting tool for weight management. More studies are needed to understand the impact on GM, for example, evaluating the production of short-chain fatty acids, since their important role in dietary metabolism. Further research is necessary to better elucidate the relationship between GM and overweight and the mechanism of action by which Lact. plantarum IMC 510 modifies body weight. SIGNIFICANCE AND IMPACT OF THE STUDY: However, these promising outcomes represent a clear advantage of probiotic supplementation and identify a new potential probiotic as a novel and safe therapeutic approach in the obesity prevention and management.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Probióticos / Lactobacillus plantarum Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Probióticos / Lactobacillus plantarum Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article