Catalytic Asymmetric Axially Chiral Allenyl C-P Bond Formation.
J Am Chem Soc
; 144(28): 12619-12626, 2022 07 20.
Article
em En
| MEDLINE
| ID: mdl-35802534
ABSTRACT
Chiral organophosphorous compounds are very important in catalysis, organic syntheses, and medicinal chemistry. However, catalytic enantioselective protocols for the axially chiral allenyl phosphorus compounds have never been reported. Herein, a palladium-catalyzed enantioselective carbon-phosphorus bond formation reaction affording axially chiral allenyl phosphonates has been developed. The reaction enjoys high yields and ees accommodating a wide range of functional groups. Mechanistic studies have unveiled an overwhelming kinetic resolution process.
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Base de dados:
MEDLINE
Assunto principal:
Paládio
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article