Scorpion Neurotoxin Syb-prII-1 Exerts Analgesic Effect through Nav1.8 Channel and MAPKs Pathway.

Bai, Fei; Song, Yongbo; Cao, Yi; Ban, Mengqi; Zhang, Zhenyu; Sun, Yang; Feng, Yuan; Li, Chunli

Bai, Fei; Song, Yongbo; Cao, Yi; Ban, Mengqi; Zhang, Zhenyu; Sun, Yang; Feng, Yuan; Li, Chunli.

Afiliação

Bai F; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.
Song Y; Department of Biochemistry, Shenyang Pharmaceutical University, Shenyang 110016, China.
Cao Y; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.
Ban M; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.
Zhang Z; Department of Biochemistry, Shenyang Pharmaceutical University, Shenyang 110016, China.
Sun Y; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.
Feng Y; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.
Li C; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.

Int J Mol Sci ; 23(13)2022 Jun 25.

Article em En | MEDLINE | ID: mdl-35806068

Assuntos

Venenos de Escorpião; Neuralgia do Trigêmeo; Analgésicos/farmacologia; Animais; Proteínas Quinases Ativadas por Mitógeno; Neurotoxinas/toxicidade; Ratos; Ratos Sprague-Dawley; Venenos de Escorpião/química; Venenos de Escorpião/farmacologia; Escorpiões/química

Palavras-chave

BmK; IoN-CCI model; MAPKs pathway; Nav1.8; Nav1.9; Syb-prII-1; VGSCs; VSD2rNav1.8; trigeminal neuralgia; ß-type scorpion neurotoxin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Venenos de Escorpião / Neuralgia do Trigêmeo Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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