[Biotransformation of psoralenoside and isopsoralenoside in Psoraleae Fructus incubated with human intestinal bacteria flora in vitro].
Zhongguo Zhong Yao Za Zhi
; 47(14): 3822-3827, 2022 Jul.
Article
em Zh
| MEDLINE
| ID: mdl-35850840
ABSTRACT
Absorption is crucial to the resultant efficacy of oral drugs where the intestinal bacteria flora functions as one of the first-pass effects.The present study investigated the biotransformation of psoralenoside and isopsoralenoside in Chinese medicine Psoraleae Fructus(the dried fruit of Psoralea corylifolia) with the internationally recognized human intestinal bacteria flora model in vitro.Pso-ralenoside and isopsoralenoside were anaerobically incubated with human intestinal bacteria flora at 37 â, respectively, and biotransformation products were analyzed and identified using high-performance liquid chromatography-tandem mass spectrometry(HPLC-MS) and comparison with reference standards.The main biotransformation products of psoralenoside were psoralen and a small amount of 6,7-furano-hydrocoumaric acid, and the main biotransformation products of isopsoralenoside were isopsoralen and a small amount of 5,6-furano-hydrocoumaric acid.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Medicamentos de Ervas Chinesas
/
Psoralea
Limite:
Humans
Idioma:
Zh
Ano de publicação:
2022
Tipo de documento:
Article