Synthetic Cannabinoids: A Pharmacological and Toxicological Overview.
Annu Rev Pharmacol Toxicol
; 63: 187-209, 2023 Jan 20.
Article
em En
| MEDLINE
| ID: mdl-35914767
ABSTRACT
Synthetic cannabinoids (SCs) are a chemically diverse group of new psychoactive substances (NPSs) that target the endocannabinoid system, triggering a plethora of actions (e.g., elevated mood sensation, relaxation, appetite stimulation) that resemble, but are more intense than, those induced by cannabis. Although some of these effects have been explored for therapeutic applications, anticipated stronger psychoactive effects than cannabis and reduced risk perception have increased the recreational use of SCs, which have dominated the NPS market in the United States and Europe over the past decade. However, rising SC-related intoxications and deaths represent a major public health concern and embody a major challenge for policy makers. Here, we review the pharmacology and toxicology of SCs. A thorough characterization of SCs' pharmacodynamics and toxicodynamics is important to better understand the main mechanisms underlying acute and chronic effects of SCs, interpret the clinical/pathological findings related to SC use, and improve SC risk awareness.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Canabinoides
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article