Reduced cytotoxicity by mutation of lysine 590 of <i>Pseudomonas</i> exotoxin can be restored in an optimized, lysine-free immunotoxin.

Reduced cytotoxicity by mutation of lysine 590 of Pseudomonas exotoxin can be restored in an optimized, lysine-free immunotoxin.

Ammon, A; Mellenthin, L; Emmerich, C; Naschberger, E; Stürzl, M; Mackensen, A; Müller, F.

Afiliação

Ammon A; Department of Internal Medicine 5, Haematology and Oncology, University Hospital of Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg (FAU), 91054 Erlangen, Germany.
Mellenthin L; Department of Internal Medicine 5, Haematology and Oncology, University Hospital of Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg (FAU), 91054 Erlangen, Germany.
Emmerich C; Department of Internal Medicine 5, Haematology and Oncology, University Hospital of Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg (FAU), 91054 Erlangen, Germany.
Naschberger E; Division of Molecular and Experimental Surgery, Translational Research Center, Department of Surgery, University Hospital of Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg (FAU), 91054 Erlangen, Germany.
Stürzl M; Division of Molecular and Experimental Surgery, Translational Research Center, Department of Surgery, University Hospital of Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg (FAU), 91054 Erlangen, Germany.
Mackensen A; Department of Internal Medicine 5, Haematology and Oncology, University Hospital of Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg (FAU), 91054 Erlangen, Germany.
Müller F; Department of Internal Medicine 5, Haematology and Oncology, University Hospital of Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg (FAU), 91054 Erlangen, Germany.

Immunother Adv ; 2(1): ltac007, 2022.

Article em En | MEDLINE | ID: mdl-35919491