Long-term nucleus basalis cholinergic depletion induces attentional deficits and impacts cortical neurons and BDNF levels without affecting the NGF synthesis.

Orciani, Chiara; Hall, Hélène; Pentz, Rowan; Foret, Morgan K; Do Carmo, Sonia; Cuello, Augusto Claudio

Orciani, Chiara; Hall, Hélène; Pentz, Rowan; Foret, Morgan K; Do Carmo, Sonia; Cuello, Augusto Claudio.

Afiliação

Orciani C; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
Hall H; Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
Pentz R; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
Foret MK; Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
Do Carmo S; Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
Cuello AC; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.

J Neurochem ; 163(2): 149-167, 2022 10.

Article em En | MEDLINE | ID: mdl-35921478

Assuntos

Prosencéfalo Basal; Colina O-Acetiltransferase; Animais; Ratos; Prosencéfalo Basal/metabolismo; Fator Neurotrófico Derivado do Encéfalo/metabolismo; Colina O-Acetiltransferase/metabolismo; Colinérgicos/farmacologia; Neurônios Colinérgicos/metabolismo; Citotoxinas; Imunoglobulina G; Ratos Wistar; RNA Mensageiro/análise; Saporinas/metabolismo; Proteínas Vesiculares de Transporte de Acetilcolina/metabolismo; Fator de Crescimento Neural/biossíntese

Palavras-chave

Alzheimer's disease; aging; basal forebrain cholinergic neurons; brain-derived neurotrophic factor; nerve growth factor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Colina O-Acetiltransferase / Prosencéfalo Basal Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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