Penetration of cefonicid in skin suction blister fluid in healthy volunteers.
Int J Clin Pharmacol Res
; 7(3): 225-7, 1987.
Article
em En
| MEDLINE
| ID: mdl-3596863
ABSTRACT
A new cephalosporin, cefonicid (1 g) was given intramuscularly to six healthy volunteers 12 h after induction of skin suction blister. Serum and blister fluid were collected during a 24 h period. Antibiotic assay was made by a microbiological method. The data were analysed by a one-compartment kinetic model. Despite the high protein binding, cefonicid penetrated in microbiologically effective concentration into blister fluid. Blister fluid concentrations were higher than the serum concentrations at 24 h.
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Base de dados:
MEDLINE
Assunto principal:
Líquidos Corporais
/
Cefamandol
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1987
Tipo de documento:
Article